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KMID : 1225720140060020142
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Allergy, Asthma & Immunology Research : AAIR
2014 Volume.6 No. 2 p.142 ~ p.148
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Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics
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Park Tae-Joon
Kim Jeong-Hyun
Pasaje Charisse F.
Park Byung-Lae
Bae Joon-Seol
Uh Soo-Taek
Kim Yong-Hoon
Kim Mi-Kyeong
Choi In-Seon S.
Choi Byoung-Whui
Shin Hye-Rim
Park Jong-Sook
Koh In-Song
Park Choon-Sik
Shin Hyoung-Doo
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Abstract
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Purpose: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 6β (ATF6B) is known to regulate ATFα-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation.
Methods: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls.
Results: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD.
Conclusions: Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics.
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KEYWORD
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ATF6B, aspirin exacerbated respiratory disease (AERD), single nucleotide polymorphism (SNP), haplotype
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